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. Author manuscript; available in PMC: 2014 Jan 29.
Published in final edited form as: Biochemistry. 2013 Jan 15;52(4):752–764. doi: 10.1021/bi300723f

Scheme 1.

Scheme 1

Synthesis of a cyclic analogue of γ-MSH Reagents: (i) assembly of linear peptide by Fmoc strategy; (ii) 20% piperidine in DMF: (iii), 4-bromo butyric acid, DIC, DMF (iv) 2%TFA/5% Et3SiH/CH2Cl2; (v) 5% DIEA/DMF; (vi) 95%TFA/5% H2O