Figure 1.

Locations and activities of W-boxes in the promoters of stress-responsive genes encoding mitochondrial protein. A, Locations of W-boxes with the TTGAC core sequence in the promoters of three widely stress-responsive genes encoding mitochondrial proteins. The red line indicates the 5′ UTR. Numbers indicate base positions upstream of the start codon. B, Relative activities of the promoter sequences fused to the GUS reporter gene compared with the promoter sequence with single or multiple W-boxes mutated. The mock-treated wild-type (WT) promoter activity was normalized to 1. Blue asterisks indicate significant differences (P < 0.05) compared with the wild-type promoter for the mock treatments, and red asterisks indicate significant differences (P < 0.05; n = 9) of the H₂O₂ treatments compared with the mock treatment of the same construct. Error bars indicate se.