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. 2013 Apr 12;3(4):e109. doi: 10.1038/bcj.2013.6

Figure 1.

Figure 1

Chemical structures of JAK1/2 dual inhibitor Compound 1 and JAK2 inhibitor Compound 2 (LY2784544). (a) Chemical structure of imidazopyridine Compound 1: 3-[(1R)-6-fluoro-2,3-dihydro-1H-inden-1-yl]-N-(3-methyl-1H-pyrazol-5-yl)-3H-imidazo[4,5-b]pyridin-5-amine dihydrochloride. (b) Chemical structure of imidazopyridazine aminopyrazole Compound 2 (LY2784544): 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine. (c) High-resolution (1.8 Å) X-ray crystal structure of LY2784544 in JAK2 kinase. JAK, janus kinase.