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In vitro culture of SI organoids reveals a defect in colony-forming ability in KO mice. (a) Organoid cultures were initiated from crebfl/fl x villinCreERT2 mice and these were exposed to 4OHT to show reduced colony-forming efficiency in the KO cultures; Means±S.E.M. two-tailed t-test; **P<0.01. (b) Representative images are shown, (mag= × 10)
