Figure 7.

Messenger RNA expression changes in selected genes identified by RNAseq studies validated by qRT-PCR. (a) Significant changes in mRNA levels for phosphatases, Pmm1b, pTen, multidrug resistance gene Abcc/Mrp2 and tyrosine kinase gene, Yes1. Four genes that encode proteins engaged in chromosome cohesion, Stag1, Stag 2, Smc2 and Smc6, are similarly lower in the crebKO small intestine crypts. Cartoons depicting the structural roles and general theme of interactions of the cohesion molecules are shown (b). Models of the structural convergence of several putative CREB target gene products, Stag1, Stag 2, Smc2 and Smc6, all of which are involved in cohesion functions, are shown