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. 2012 Aug 29;21(5):517–521. doi: 10.1038/ejhg.2012.197

Figure 1.

Figure 1

Luciferase (LUC) reporter assays of GDF5 promoter/5′-UTR constructs in the osteogenic MG63 cell line (a) and the chondrogenic SW1353 cell line (b). A schematic drawing of the promoter/5′ UTR construct is shown at the top left of each panel and highlights the relative positions of the −41 bp, rs143383 and rs143384 polymorphisms. Data are the fold expression in relation to the control empty pGL3 vector, and are shown as the mean and standard error (SE) of the mean from three independent experiments, each performed with six biological replicates. P-values were calculated using a Student's t-test. *P<0.05, **P<0.01, ***P<0.001; NS, not significant.