Table 1. Genome-wide significant polymorphisms on chromosome 19 associated with familial hypercholesterolemia.

Polymorphism	Position	Allele	The Rotterdam study MAF	ARGOSMAF	OR	P-value
rs7259203	8 672 833a	A	0.16	0.24	1.71	4.32 × 10−11
rs2033483	9 115 342a	G	0.11	0.18	1.76	6.51 × 10−10
rs10422772	9 584 423a	A	0.14	0.08	0.49	1.41 × 10−8
rs10405652	9 602 123a	A	0.14	0.08	0.49	2.03 × 10−8
rs10411082	9 602 216a	A	0.21	0.13	0.58	4.51 × 10−8
rs10418705	9 629 925a	G	0.20	0.13	0.57	3.16 × 10−8
rs10417523	9 681 194a	C	0.14	0.07	0.48	1.87 × 10−8
rs10415132	9 724 483a	A	0.21	0.13	0.57	2.08 × 10−8
rs7247038	9 739 695a	G	0.21	0.13	0.58	4.16 × 10−8
rs2431820	9 996 284a	G	0.06	0.11	2.09	1.05 × 10−10
rs10417403	10 033 516a	G	0.26	0.34	1.50	3.33 × 10−8
rs3745264	10 290 566	A	0.15	0.25	1.97	6.00 × 10−17
rs7507634	10 297 562	A	0.11	0.22	2.24	1.36 × 10−20
rs2304240	10 310 392	A	0.16	0.33	2.63	2.21 × 10−35
rs280519	10 333 933	G	0.50	0.40	0.67	1.78 × 10−8
rs8112449	10 381 064	A	0.30	0.22	0.63	3.63 × 10−8
rs7256672	10 440 474	C	0.36	0.45	1.49	1.14 × 10−8
rs1529711	10 884 434	A	0.16	0.25	1.73	8.58 × 10−12
rs4804149	11 145 028	G	0.29	0.40	1.64	1.83 × 10−12
rs387865	11 145 539	A	0.29	0.39	1.57	1.61 × 10−10
rs8111456	11 162 147	G	0.34	0.44	1.54	3.30 × 10−10
rs313624	11 413 910	A	0.48	0.43	1.48	2.18 × 10−8
rs4804636	11 703 323	A	0.34	0.45	1.58	3.15 × 10−11
rs286262	11 708 615	A	0.37	0.48	1.55	2.43 × 10−10
rs11880217	12 279 795a	A	0.16	0.24	1.66	4.89 × 10−10
rs12610507	12 297 410a	C	0.17	0.25	1.62	1.70 × 10−9
rs2967890	12 901 647a	G	0.23	0.31	1.55	2.91 × 10−9
rs16042	13 202 037a	A	0.11	0.17	1.76	7.05 × 10−10

Abbreviations: LDL, low-density lipoprotein; MAF, minor allele frequency; OR, odds ratio.

^aLocated 1-2 Mb from the LDLR gene (located 11 061 132–11 105 490 according to HapMap). The other polymorphisms are located<1 Mb from the LDLR gene.