Table 4. Correlations of metabolites with proteins in all participants.

Proteins	Metabolites	Correlation coefficient	P-value	q-value
Ab42	11–46.55	−0.36	<0.001	0.006
	MET	−0.33	<0.001	0.008
	11–36.75	−0.33	<0.001	0.008
	13–18.475	−0.32	<0.001	0.008
	15–65.533	−0.28	0.004	0.03
	VMA	−0.28	0.005	0.03
	9–20.858	−0.27	0.005	0.03
	5–102.808	−0.26	0.008	0.03
	GSH	−0.25	0.01	0.04
p-tau	13–44.608	0.44	<0.001	<0.001
	12–41.200	0.36	<0.001	0.002
	XAN	0.36	<0.001	0.002
	VMA	0.29	0.002	0.01
	11–46.55	0.31	0.002	0.01
	11–60.917	0.30	0.002	0.01
	XANTH	0.28	0.004	0.02
	4-HPLA	0.27	0.006	0.02
	HVA	0.26	0.007	0.02
	GSH	0.26	0.007	0.02
	13–74.392	0.26	0.008	0.02
	9–20.858	0.25	0.01	0.02
	14–22.758	−0.25	0.01	0.02
	9–29.34	0.25	0.01	0.02
	9–29.925	0.24	0.01	0.02
	14–34.25	0.22	0.03	0.04
t-tau	13–44.608	0.59	<0.001	<0.001
	XAN	0.44	<0.001	<0.001
	12–41.200	0.41	<0.001	<0.001
	11–46.55	0.39	<0.001	<0.001
	13–78.992	0.35	<0.001	0.003
	4-HPLA	0.33	<0.001	0.006
	9–29.925	0.33	<0.001	0.007
	5-HIAA	0.32	<0.001	0.009
	9–20.858	0.31	0.001	0.01
	VMA	0.30	0.002	0.02
	8–14.983	0.28	0.004	0.03
	GSH	0.27	0.005	0.03
	14–34.25	0.26	0.007	0.04
	URIC	0.25	0.01	0.04
	2-HPAC	0.25	0.01	0.04
	XANTH	0.25	0.01	0.04
	9–25.825	0.25	0.009	0.04
	11–60.917	0.26	0.008	0.04
	9–29.34	0.25	0.01	0.04

Abbreviations: Ab42, amyloid-β p-tau, phosphorylated tau; t-tau, total tau. For expansions of the metabolite abbreviations, see Table 2.

Significance cutoff: q-value <0.05.