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. 2013 Apr 16;3(4):e247. doi: 10.1038/tp.2013.21

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Fold change in mRNA expression of myelin lipid-related enzymes in the prefrontal cortex (PFC) of adolescent animals treated with gestational nicotine (GN; black bars) or saline (GS; white bars). Four genes, UDP glycosyltransferase 8 (Ugt8), aspartoacylase (Aspa), farnesyl diphosphate farnesyl transferase 1 (Fdft1) and galactosylceramidase (Galc), were evaluated using quantitative real-time PCR in both males (a) and females (b). The three-way mixed-design analysis of variance with two between-subject factors (that is, sex and drug) and one within-subject factor (that is, gene) showed a significant sex effect (F_{1, 17}=11.458, P=0.004) and an interaction of sex and drug (F_{1, 17}=15.901; P=0.001). Data are expressed as means±s.e.m. *P<0.05, ***P<0.001 significantly different from GS (N=5 or 6).