Table 2. Univariate and multivariate Cox regression models for progression to psychosis (N=225).

Variables	Model 1		Model 2		Model 3
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Univariate models
rs4281084 (NRG1)	1.55 (1.05–2.27)	0.027
rs12155594 (NRG1)			2.29 (1.39–3.78)	0.001
Number of risk allelesa					1.56 (1.20–2.04)	0.001
Multivariate models
rs4281084	1.48 (0.97–2.25)	0.071
rs12155594			2.06 (1.21–3.49)	0.008
Number of risk allelesa					1.47 (1.11–1.95)	0.007
Age	0.97 (0.89–1.05)	0.428	0.97 (0.89–1.05)	0.410	0.97 (0.88–1.05)	0.415
Sex	1.00 (0.57–1.76)	0.999	1.04 (0.59–1.82)	0.907	1.00 (0.57–1.76)	0.999
Duration of symptomsb	1.00 (1.00–1.01)	0.105	1.00 (1.00–1.01)	0.076	1.00 (1.00–1.01)	0.112
GAF score	0.95 (0.92–0.98)	0.002	0.95 (0.92–0.98)	0.003	0.95 (0.92–0.98)	0.002
BPRS total score	0.95 (0.90–0.99)	0.042	0.95 (0.91–1.01)	0.078	0.95 (0.90–0.99)	0.048
BPRS psychotic subscale	1.07 (0.93–1.24)	0.340	1.08 (0.92–1.24)	0.340	1.08 (0.93–1.25)	0.319
SANS attention subscale	1.10 (0.95–1.28)	0.195	1.09 (0.94–1.27)	0.239	1.10 (0.94–1.27)	0.237
Cannabis use (yes)	0.34 (0.10–1.31)	0.078	0.31 (0.09–1.03)	0.060	0.31 (0.09–1.07)	0.064

Abbreviations: BPRS, Brief Psychiatric Rating Scale; CI, confidence interval; GAF, Global Assessment of Functioning; HR, hazard ratio; SANS, Scale for the Assessment of Negative Symptoms.

^ars4281084 A-alleles+rs1255594 T-alleles.

^bTime between onset of symptoms and first contact with PACE Clinic.