Table 2. Adjusted mean inflammatory marker levels across anxiety groups.

	Controls			Remitted anxiety disorder			Current anxiety disorder
	Mean	(s.e.)	P	Mean	(s.e.)	P	Mean	(s.e.)	P
				CRP, mg l−1a
Total sample	N=556			N=459			N=1273
Unadjustedb	1.11	(1.05)	Ref	1.25	(1.06)	0.14	1.36	(1.04)	0.001
Adjustedc	1.20	(1.05)	Ref	1.24	(1.06)	0.66	1.33	(1.03)	0.10
Adjustedd	1.28	(1.05)	Ref	1.21	(1.05)	0.46	1.30	(1.03)	0.74
Sex-interactione						0.57			0.002
Men	N=219			N=131			N=407
Unadjustedb	0.84	(1.08)	Ref	1.02	(1.11)	0.15	1.25	(1.06)	<0.001
Adjustedc	0.90	(1.08)	Ref	0.98	(1.10)	0.50	1.22	(1.06)	0.002
Adjustedd	0.98	(1.07)	Ref	0.96	(1.09)	0.82	1.18	(1.05)	0.04
Women	N=337			N=328			N=866
Unadjustedb	1.34	(1.07)	Ref	1.35	(1.07)	0.89	1.42	(1.04)	0.46
Adjustedc	1.41	(1.07)	Ref	1.40	(1.07)	0.95	1.37	(1.04)	0.74
Adjustedd	1.48	(1.06)	Ref	1.36	(1.06)	0.35	1.36	(1.04)	0.26
				IL-6, pg ml−1a
Total sample	N=556			N=459			N=1273
Unadjustedb	0.73	(1.04)	Ref	0.71	(1.05)	0.78	0.79	(1.03)	0.08
Adjustedc	0.75	(1.04)	Ref	0.70	(1.05)	0.30	0.78	(1.03)	0.35
Adjustedd	0.79	(1.04)	Ref	0.70	(1.04)	0.06	0.77	(1.03)	0.63
Sex-interactione						0.47			0.40
				TNF-α, pg ml−1a
Total sample	N=556			N=459			N=1273
Unadjustedb	0.82	(1.03)	Ref	0.81	(1.03)	0.75	0.83	(1.02)	0.73
Adjustedc	0.84	(1.03)	Ref	0.81	(1.03)	0.43	0.83	(1.02)	0.75
Adjustedd	0.85	(1.03)	Ref	0.82	(1.03)	0.35	0.82	(1.02)	0.41
Sex-interactione						0.92			0.87

Abbreviations: CRP, C-reactive protein; IL-6, interleukin-6; TNF-α, tumor necrosis factor-α.

^aTo normalize distributions CRP, IL-6 and TNF-α were ln-transformed; for interpretation purposes presented means are back-transformed.

^bBased on analyses of variance.

^cBased on analyses of covariance adjusted for (sex,) age and education.

^dBased on analyses of covariance additionally adjusted for smoking status, alcohol intake, physical activity, body mass index, cardiovascular disease, diabetes, number of other chronic diseases, statins and anti-inflammatory medication.

^eSex-interactions are based on the fully adjusted model including anxiety status and a sex × anxiety status interaction term.