Table 1. Comparison of sociodemographic, general clinical and anxiety/claustrophobia relevant parameters in claustrophobic and non-claustrophobic subjects independent of mutation status.

	Total sample (N=115)		Claustrophobic subjects (N=47)		Non-claustrophobic subjects (N=68)		Statistics Pa
	Mean±s.d.		Mean± s.d.		Mean± s.d.
Sociodemographics
Age in years	43.56±13.22		43.87±12.11		43.35±14.02		0.733
Education in years	14.43±3.55		14.31±3.85		14.52±3.35		0.830
	N	%	N	%	N	%	Effect	Pb
Gender
Female	81	70.4	13	27.7	21	30.9	0.139	0.710
Male	34	29.6	34	72.3	47	69.1
Ethnicity
Caucasian	112	97.4	47	100.0	65	95.6	2.129	0.546
African	1	0.87	—	—	1	1.47
Other	2	1.73	—	—	2	9.94
Marital status
Single	57	49.6	24	51.1	33	48.5	3.545	0.471
Married	33	28.7	12	25.5	21	30.9
Divorced	19	16.5	11	23.4	11	16.2
Widowed	3	2.6	—	—	3	4.4
Main diagnoses according to DSM-IV
No clinical diagnosis	27	23.5	13	27.7	14	20.6	1.135	0.567
Schizophrenia	43	37.4	18	38.3	25	36.8
Other clinical diagnoses	45	39.0	16	34.0	29	43
Prevalence of anxiety disorders
Comorbid anxiety disorderc	68	59.1	29	61.7	39	57.4	0.702
Panic disorder	29	25.2	15	31.9	14	20.6	0.194
Agoraphobiad	56	48.7	47	100.0	9	13.2	<0.0001
Ssocial phobia	18	15.7	9	19.1	9	13.2	0.440
Specific phobia	38	33.0	20	42.6	18	26.5	0.106
Generalized anxiety disorder	13	11.3	7	14.9	6	8.8	0.375
Obsessive compulsive disorder	18	15.7	9	19.1	9	13.2	0.440
	Mean±s.d.		Mean±s.d.		Mean±s.d.		Pa
Claustrophobia Relevant Items (Short CLQ-G)
Subscale ‘restriction'
Dark room	2.18±1.66		3.25±1.22		1.44±1.51		<0.000001
Well-lit room	1.51±1.46		2.53±1.27		0.78±1.12		<0.000001
Sleeping bag	1.04±1.45		1.87±1.58		0.47±1.01		<0.000001
Trunk	2.18±1.67		3.53±1.04		1.25±1.36		<0.000001
MRI scanner	1.65±1.67		3.17±1.05		0.60± 1.11		<0.000001
Mean of subscale	1.71±1.36		2.87±0.87		0.91±1.00		<0.000001
Subscale ‘suffocation'
Elevator	1.07±1.39		2.13±1.36		0.34±0.84		<0.000001
Breathe	0.83±1.09		1.26±1.24		0.54±0.87		<0.001
Crowded room	1.82±1.57		3.04±1.12		0.97±1.25		<0.000001
Under a car	1.23±1.44		2.17±1.51		0.59±0.97		<0.000001
Sauna	1.00±1.44		2.04±1.56		0.28±0.75		<0.000001
Mean of subscale	1.19±1.08		2.13±0.83		0.54±0.70		<0.000001
Mean of questionnaire	1.45±1.17		2.50±0.74		0.73±0.82		<0.000001

Abbreviation: MRI, magnetic resonance imaging.

^aMann–Whitney U-test.

^bFisher's exact test/χ²-square test.

^cAnxiety disorders other than agoraphobia.

^dAgoraphobia includes claustrophobia.