Table 1. Characteristics of Amish PAPI Study and Sinai Hospital of Baltimore Study Participants.
| Characteristic, Units | Amish PAPIa | Sinai Hospital of Baltimore | ||
|---|---|---|---|---|
| Men | Women | Men | Women | |
| No. (%) | 214 (49.9) | 215 (50.1) | 136 (59.9) | 91 (40.1) |
| Age, mean (SD), y | 43.9 (13.2) | 47.3 (14.4) | 62.5 (11.4) | 67.0 (11.0) |
| White, No. (%) | 214 (100) | 215 (100) | 93 (68.4) | 47 (51.6) |
| Body mass index, mean (SD)b | 26.0 (3.7) | 28.3 (5.6) | 30.1 (6.3) | 30.9 (7.1) |
| Blood pressure, mean (SD), mm Hg | ||||
| Systolic | 116.6 (12.0) | 117.4 (14.0) | 138.0 (19.9) | 144.6 (19.9) |
| Diastolic | 70.8 (7.4) | 69.7 (7.5) | 73.6 (13.8) | 70.3 (14.2) |
| Hypertension, No. (%)c | 11 (5.1) | 13 (6.0) | 102 (75.0) | 72 (79.1) |
| Lipids, mean (SD), mg/dL | ||||
| Total cholesterol | 206.0 (44.8) | 217.9 (52.2) | NA | NA |
| LDL-C | 137.7 (41.5) | 141.0 (48.9) | NA | NA |
| HDL-C | 54.7 (15.0) | 61.6 (15.2) | NA | NA |
| Triglyceridesd | 68.1 (40.4) | 76.0 (39.4) | NA | NA |
| Hypercholesterolemia, No. (%)e | 52 (24.3) | 59 (27.4) | 111 (81.6) | 72 (79.1) |
| Taking aspirin, No. (%) | 6 (2.8) | 3 (1.4) | 136 (100) | 91 (100) |
| Self-reported diabetes, No. (%) | 1 (0.5) | 2 (0.9) | 39 (28.7) | 44 (48.4) |
| Hematocrit, mean (SD), % | 41.3 (2.4) | 37.7 (2.3) | 41.8 (5.0) | 37.9 (4.5) |
| White blood cell count, median (IQR), × 1000/μL | 5.8 (5.1-6.7) | 5.8 (5.1-6.8) | 6.8 (5.7-8.2) | 7.5 (6.0-9.2) |
| Platelet count, mean (SD) × 100 000/μL | 240.9 (43.7) | 248.1 (50.3) | 223.6 (68.5) | 252.2 (71.4) |
| Current smoker, No. (%)f | 38 (17.8) | 0 | 40 (29.4) | 18 (19.8) |
Abbreviations: HDL-C, high-density lipoprotein cholesterol; IQR, interquartile range; LDL-C, low-density lipoprotein cholesterol; NA, not available; PAPI, Pharmacogenomics of Anti-Platelet Intervention.
SI conversion factors: To convert HDL-C, LDL-C, and total cholesterol values to mmol/L, multiply by 0.0259; triglyceride values to mmol/L, multiply by 0.0113.
For PAPI Study, all participants were withdrawn from prescription and nonprescription medications, vitamins, and supplements 7 days prior to and for the duration of the study. Participants taking prescription antihypertensive, lipid-lowering, and diabetes medications accounted for 0%, 1.6%, and 0% of participants, respectively.
Calculated as weight in kilograms divided by height in meters squared.
Defined as systolic blood pressure greater than 140 mm Hg or diastolic blood pressure greater than 90 mm Hg or taking prescription medication for previously diagnosed hypertension.
Logarithm-transformed for analysis and back-transformed for presentation.
Defined as LDL-C level greater than 160 mg/dL or taking prescription medication for previously diagnosed hyper-cholesterolemia.
Self-reported history of smoking cigarette, pipe, or cigar.