Table 2.

SNP odds ratios per allele for men and women combined, adjusted for age, gender, height, and weight, in additive model for any single joint with K/L > 1 in the listed distribution. rs1256034 and rs944460 as listed here are analyzed in a dominant model due to their small allele sizes. Table cells list genotype counts for the common homozygote, heterozygote, and rare homozygote; counts on the first line are for unaffected and on second line for affected subjects. Totals differ slightly in some cases due to missing data.

Genotype Counts	DIP OA	PIP OA	CMC OA
ESR1 SNP
rs2234693
Unaffected	105/140/69	115/155/75	97/146/67
Affected	61/105/35	51/90/29	69/99/37
OR (95% CI)	1.01 (0.76, 1.35)	0.99 (0.74, 1.32)	0.87 (0.67, 1.16)
rs9340799
Unaffected	139/129/49	154/141/54	133/135/45
Affected	94/86/24	79/74/19	100/80/28
OR (95% CI)	0.92 (0.68, 1.23)	0.88 (0.66, 1.19)	0.86 (0.65, 1.15)
rs2077647
Unaffected	97/154/62	103/177/63	93/158/56
Affected	59/114/28	53/91/27	63/110/34
OR (95% CI)	0.97 (0.72, 1.32)	0.93 (0.69, 1.26)	1.01 (0.75, 1.35)
rs1801132
Unaffected	182/103/16	200/113/16	171/100/19
Affected	109/72/8	91/62/8	120/75/5
OR (95% CI)	1.01 (0.70, 1.46)	1.24 (0.87, 1.78)	0.77 (0.54, 1.10)
ESR2 SNP
rs1256031
Unaffected	94/147/79	102/165/86	87/157/70
Affected	65/96/41	57/78/34	72/86/50
OR (95% CI)	1.00 (0.75, 1.33)	0.91 (0.69, 1.21)	1.00 (0.76, 1.32)
rs1256034
Unaffected	301/18/0	329/21/0	289/22/0
Affected	176/19/0	148/16/0	188/15/0
OR (95% CI)	1.61 (0.73, 3.55)	1.67 (0.78, 3.57)	0.81 (0.37, 1.76)
rs1256059
Unaffected	97/156/60	103/175/67	89/166/52
Affected	61/104/35	55/85/28	69/94/43
OR (95% CI)	1.06 (0.78, 1.43)	0.89 (0.66, 1.19)	1.02 (0.76, 1.36)
rs944460
Unaffected	306/16/0	324/20/0	292/21/0
Affected	181/19/0	153/15/0	195/14/0
OR (95% CI)	2.00 (0.88, 4.52)	1.73 (0.79, 3.77)	0.83 (0.38, 1.84)

K/L: Kellgren Lawrence; DIP: distal interphalangeal; PIP: proximal interphalangeal; CMC: carpometacarpal.