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. 2013 Feb 19;23(5):588–589. doi: 10.1038/cr.2013.26

Figure 1.

Figure 1

Effect of uptake of apoptotic cells on process of allergic sensitization. Apoptotic cells are endocytosed via an unknown dead cell receptor in a process requiring the small GTPase Rac1. Engulfment of apoptotic cells leads to secretion of IL-10 and TGFβ that most likely suppresses the functions of DCs. Additionally there is a block of IL-33 production, suppressing the activation of DCs and ILC2s. DCs are crucial in mounting Th2 immunity to allergens, whereas ILC2s are emerging as effector cells in allergy by secretion of IL-5 and IL-13.