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. 2013 Mar 5;23(5):705–719. doi: 10.1038/cr.2013.31

Figure 7.

Figure 7

mSSB1 deletion results in neonatal lethality and increased genomic instability. (A) mSSB1 deletion results in neonatal lethality. Table of mSSB1Δ/+ intercrosses. (B) Images of neonatal mSSB1Δ/Δ pup and WT littermate. Arrow points to abnormal hindlimb. (C) Detection of mSSB1 and mSSB2 in lungs from P0 WT or mSSB1Δ/Δ pups. (D) Immunoblot detection of mSSB1 and mSSB2 in adult testis and lungs from WT or mSSB1F/F mice. (E) Immunoblot detection of mSSB1, mSSB2, pATM, pChk2 in WT or mSSB1F/F MEFs with or without exposure to 5-Gy IR. (F) Quantification of total chromosome aberrations in mSSB1F/F and WT MEFs untreated or exposed to 5-Gy IR. (G) Kaplan-Meier survival analysis of mSSB1F/F and mSSB1F/+ controls. (H) Significant difference in the ratio of spleen to body weight of age-matched female WT or mSSB1F/+ mice (others) and mSSB1F/F mice. (I) mSSB1F/F;p53−/− female mice display disseminated lymphomas, with invasion into livers (top) and kidneys (bottom). Scale bar, 25 μm.