Table 3.
Association of patient and laboratory report characteristics with undocumented CKD
| Variable | Unadjusted Odds Ratio for Undocumented CKD (95% CI) | Odds Ratio for Undocumented CKD Adjusted for Main Effects (95% CI)a | Adjusted Odds Ratio for Undocumented CKDb from Analysis with Interaction Term | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All Subjects | From Stratified Analysis | All Subjects | From Stratified Analysisc | ||||||
| Males | Females | Males | Females | SCr only | eGFR | Pd | |||
| Sex | Sex × report format 0.04 | ||||||||
| Females (REF: male) | 1.75 (1.35, 2.26) | 2.93 (2.04, 4.21) | 3.81 (2.43, 5.96) | 2.14 (1.37, 3.33) | |||||
| Males | Females | ||||||||
| Laboratory reporting | |||||||||
| SCr only (REF: eGFR) | 0.97 (0.64, 1.49) | 0.69 (0.40, 1.20) | 1.61 (0.99, 2.62) | 0.89 (0.57, 1.40) | 0.66 (0.37, 1.16) | 1.76 (1.02, 3.02) | 0.64 (0.37, 1.12) | 1.14 (0.71, 1.86) | |
| eGFR at inclusion (ml/min per 1.73 m2) | <0.01 | ||||||||
| 40–59 (REF: <30) | 4.17 (2.38, 7.32) | 5.09 (2.14 12.07) | 36.13 (3.27, 398.30) | 9.29 (4.57, 18.87) | 5.63 (2.34, 13.56) | 73.3 (8.72, 616.5) | 9.27 (4.57, 18.78) | ||
| 30–44 (REF: <30) | 3.34 (2.06, 5.39) | 2.50 (1.16, 5.37) | 4.14 (2.35, 7.31) | 4.18 (2.49, 7.03) | 2.83 (1.30, 6.15) | 4.74 (2.65, 8.48) | 4.23 (2.50, 7.18) | ||
| Comorbidity | |||||||||
| No DM (REF: DM) | 1.47 (1.15, 1.90) | 1.29 (0.86, 1.92) | 1.48 (1.04, 2.09) | 1.26 (0.98, 1.62) | 1.20 (0.82, 1.77) | 1.23 (0.81, 1.86) | 1.58 (1.23, 2.03) | 0.08 | |
| No HTN (REF: HTN) | 1.50 (1.01, 2.23) | 1.30 (0.82, 2.08) | 2.19 (1.15, 4.17) | 1.53 (1.03, 2.26) | 1.17 (0.75, 1.83) | 2.19 (1.13, 4.26) | 1.62 (1.10, 2.37) | 0.03 | |
| Age (yr) | 0.03 | ||||||||
| <60 (REF: 85+) | 0.89 (0.50, 1.59) | 1.16 (0.52, 2.60) | 0.69 (0.32, 1.49) | 0.75 (0.41, 1.39) | 0.98 (0.44, 2.21) | 0.33 (0.15, 0.72) | 0.76 (0.41, 1.38) | ||
| 60–74 (REF: 85+) | 0.65 (0.44, 0.94) | 0.64 (0.39, 1.05) | 0.62 (0.36, 1.08) | 0.57 (0.38, 0.86) | 0.50 (0.28, 0.90) | 0.60 (0.32, 1.11) | 0.58 (0.38, 0.88) | ||
| 75–84 (REF: 85+) | 0.97 (0.71, 1.32) | 1.00 (0.59, 1.68) | 0.99 (0.63, 1.55) | 0.97 (0.71, 1.33) | 0.89 (0.53, 1.53) | 1.02 (0.62, 1.68) | 0.99 (0.72, 1.35) | ||
CI, confidence interval; SCr, serum creatinine; eGFR, estimated GFR; REF, reference category for odds ratio; DM, diabetes mellitus; HTN, hypertension.
a
Adjusted for sex, eGFR at inclusion, age, DM, HTN, and report format.
b
Adjusted for sex, eGFR at inclusion, age, DM, HTN, report format, and sex × eGFR report. If sex × eGFR at inclusion was added to the model, the significance level for the interaction would be P=0.06.
c
Separate models stratified by sex adjusted for eGFR at inclusion, age, DM, HTN, and report format.
d
P values are the significance levels for the factors and interaction terms.