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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Drug Discov Today Technol. 2012 Mar 29;10(1):e121–e128. doi: 10.1016/j.ddtec.2012.02.003

Figure 2. Structures of compounds derived from recent PD-relevant HT screens.

Figure 2

Structures of compounds identified in the last two years. (A,B) Compounds identified in a reporter-based cell culture screen modulate α-syn expression via its unique 5′ UTR structure. (C) A screen for natural products similarly identified Strophanthidine as a specific modulator of α-syn’s 5′ UTR translational regulation. (D) Carnosic acid, a compound identified by its ability to rescue cells from rotenone toxicity. (E) A series of tetrahydroquinolinones identified from a yeast model of α-syn toxicity were validated in multiple neuronal assays. Bracketed numbers indicate references.