Fig. 4.

A study-specific template (target for the registration) caused less systematic accumulation of areal quantities across the brain when compared with a non-specific template. Using default parameters, areal accumulation was less pronounced and unrelated to sulcal patterns using Spherical Demons in comparison with FreeSurfer registration. Gains and losses refer to the area per face that would be expected for areal quantities being redistributed with no bias, i.e. the zero corresponds to the average total surface area of all subjects, divided by the number of faces.