Figure 2.

“Right ventricle; changes of the microcirculation (A-C). Confocal microscopy of in vivo labeled right heart muscle capillaries; immunohistochemistry, tomato lectin stain = red (A,B). One single capillary lumen, electron microscopy, in vivo fixation. The image shows destruction of the endothelial cell with bleb formation (C). Trichrome stain (D,E), expression of connective tissue growth factor (CTGF) gene in the failing (Su/Hx) right ventricle (F). Electron microscopy, normal right ventricle mitochondrial morphology (G), small, dense mitochondria in the Su/Hx failing right venticle (H). Reduction of mitochondria (mitochondrial yield) in the Su/Hx failing right ventricle.