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. 2013 Jan-Mar;3(1):144–152. doi: 10.4103/2045-8932.109960

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Copyright: © Pulmonary Circulation

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Increased glycolysis in the RV in experimental RVH in PAH patients. (A) Increased RV FDG-PET in MCT models is reduced by dichloroacetate (DCA). (B) Increased Glut1 expression in RV myocyte membranes in a monocrotaline (MCT) model is reduced by DCA. (C) RV PDH activity is reduced in MCT and PAB, especially in MCT model. (D) The cross sections of RVs from patients with adaptive versus maladaptive RVH. RV chambers are enlarged in both patients however adaptive RVH is concentric with less dilatation and fibrosis. (E and F) Immunostaining shows up-regulation of Glut1 and PDK4 expression in RV myocytes is less profound in the PAH patient with adaptive RVH. The figure is partially adapted from references 13 and 21, with permission.