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. Author manuscript; available in PMC: 2013 Jun 22.
Published in final edited form as: Cell. 2012 May 10;149(7):1607–1621. doi: 10.1016/j.cell.2012.04.012

Figure 1. De novo predicted 3D models of membrane proteins with no known structure (related to Figure S1).

Figure 1

Cartoon shows evolutionary couplings as calculated by EVfold – membrane placed as distance constraints on extended polypeptide before folding. Top ranked models of a representative set of 6 transmembrane proteins from diverse families, which have no members with known 3D structures. Models are cartoon representation with rainbow coloring blue N terminal to red C terminal, seen from the side (left) and non-cytoplasmic side (right). Naming conventions, 3D coordinates and input files in Tables 1, S1 Data S1, Data S2–5.