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A schematic of step-wise gold nanoshell formation followed by biofunctionalization. (i) Gold acetate/oleic acid/oleylamine (R=oleic acid/oleylamine) (ii) Cysteamine hydrochloride (iii) LHRH/EDC at 4 °C. (a) SPIONs (b) SPIONs@Au (c) SPIONs@Au-Cysteamine and (d) SPIONs@Au-Cysteamine-LHRH.
