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. Author manuscript; available in PMC: 2013 May 2.
Published in final edited form as: J Am Chem Soc. 2011 Apr 27;133(19):7361–7375. doi: 10.1021/ja108118v

Figure 8.

Figure 8

ITC profile of 3 with (A) d[5’-A12-x-T12-3’], (B) d[5’-G3A5T5C3-3’], (C) d[5’- G3(AT)5C3-3’], and (D) d[5’- A3G5C5T3-3’]. Top Panel: ITC titrations represent the heat burst curves and each heat burst curve is result of 9 μL injection of 125 μM of 3 into the DNA duplex. The area under each heat burst curve was calculated by integration and yields the associated injection heats which were then plotted as a function of molar ratio of drug to DNA in the lower panel in each figure. Lower Panel: Corrected injection heats plotted as a function of the [drug]/DNA ratio. Buffer conditions: 100 mM KCl, 10 mM SC, 0.5 mM EDTA, pH 6.8. T = 25 °C. [DNA] = 4 μM/duplex. [3] = 125 μM.