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. Author manuscript; available in PMC: 2013 May 2.
Published in final edited form as: Biochemistry. 2010 Jul 6;49(26):5540–5552. doi: 10.1021/bi100071j

Table 1.

AC50 values of various neomycin conjugates to DNA triplex. Buffer conditions: 150 mM KCl, 10 mM SC, 0.5 mM EDTA. [5’-dA12-x-dT12-x-dT12-3’] = 100 nM/strand, [TO] = 700 nM. [poly(dA)•2poly(dT)] = 0.88 µM/bt, [TO] = 1.25 µm.

Aminoglycoside conjugate AC50
[5’-dA12-x-dT12-x-dT12-3’]		 AC50
[poly(dA)•2poly(dT)]
6 1.59±0.04 µM
8 4.4±0.7 µM
7 7.2±0.9 µM
2 379±86 nM 124±18 nM
4 713±123 nM 138±20 nM
1 1.78±0.32 µM 366±13 nM
3 5.37±1.46 µM 1.56±0.29 µM
Neomycin 47.4±2.1 µM 3.0±0.6 µM