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. Author manuscript; available in PMC: 2013 May 2.
Published in final edited form as: Biochemistry. 2010 Jul 6;49(26):5540–5552. doi: 10.1021/bi100071j

Table 2.

The UV melting temperatures recorded when poly(dA)•2poly(dT) dissociates in the presence of intercalator-neomycin conjugates (1–4) at various concentrations. Tm3→2: The melting temperatures representing the transition when poly(dA)•2poly(dT) dissociates into poly(dA)•poly(dT) and poly(dT). Tm2→1: The melting temperatures representing the transition when poly(dA)•poly(dT) dissociates into poly(dA) and poly(dT).

Concentration of 1 (µM) Tm3→2 Tm2→1
0 34 72
1 43 72
2 56 72
4 59 73
Concentration of 2 (µM) Tm3→2 Tm2→1
0 34 72
2 80 (Tm3→1) -
4 86 (Tm3→1) -
Concentration of 3 (µM) Tm3→2 Tm2→1
0 34 72
1 54 72
2 65 73
4 70 75
Concentration of 4 (µM) Tm3→2 Tm2→1
0 34 72
1 60 74
2 68 74
4 74 80