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UV melting profiles of Oxytricha Nova quadruplex (GGGGTTTTGGGG)2 in the presence of various ligands. The oligonucleotides concentration was 10 μM/ str while the ligand concentrations were 1:1 quadruplex/ ligand ratio in buffer 10mM Sodium Cacoldylate, 0.5 mM EDTA and 100 mM NaCl at pH 7.0.The nucleic acid samples were heated at the rate of 0.2 deg/min. The melting temperatures were determined by the first derivative analysis.
