Table 2.
Distribution of OPRM1 genotypes and alleles between SZ cases and controls in all, female and male samples*
|
SNP |
Haplotype/Allele |
All |
|
|
|
Male |
|
|
|
Female |
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Cases | OR (95%) | P value | Controls | Cases | OR (95%) | P value | Controls | Cases | OR (95%) | P value | ||
| rs799971 |
AA |
68 |
132 |
1.00(referent) |
|
31 |
93 |
1.00(referent) |
|
37 |
39 |
1.00(referent) |
|
| |
AG |
133 |
102 |
0.417(0.281-0.618) |
<0.00001 |
85 |
50 |
0.208(0.121-0.358) |
<0.00001 |
48 |
52 |
1.063(0.582-1.941) |
0.84 |
| |
GG |
63 |
30 |
0.257(0.152-0.436) |
<0.00001 |
30 |
11 |
0.127(0.057-0286) |
<0.0.00001 |
33 |
19 |
0.564(0.273-1.164) |
0.12 |
| |
A |
269 |
366 |
1.00(referent) |
|
147 |
236 |
1.00(referent) |
|
122 |
130 |
1.00(referent) |
|
| |
G |
259 |
162 |
0.46(0.357-0.59) |
<0.00001 |
145 |
72 |
0.309(0.218-0.439) |
<0.00001 |
114 |
90 |
0.741(0.511-1.073) |
0.11 |
| |
HWE(P) |
0.9 |
0.14 |
|
|
0.4 |
1.00 |
|
|
0.37 |
0.68 |
|
|
| rs2075572 |
CC |
140 |
166 |
1.00(referent) |
|
79 |
84 |
1.00(referent) |
|
61 |
82 |
1.00(referent) |
|
| |
CG |
100 |
82 |
0.697(0.481-1.010) |
0.06 |
51 |
55 |
1.053(0.643-1.725) |
0.84 |
49 |
27 |
0.383(0.213-0.689) |
0 |
| |
GG |
24 |
16 |
0.594(0.301-1.171) |
0.59 |
16 |
15 |
0.951(0.437-2.071) |
0.9 |
8 |
1 |
0.087(0.01-0.723) |
0.02 |
| |
C |
380 |
414 |
1.00(referent) |
|
209 |
223 |
1.00(referent) |
|
171 |
191 |
1.00(referent) |
|
| |
G |
148 |
114 |
0.707(0.534-0.937) |
0.02 |
83 |
85 |
0.96(0.672-1.371) |
0.82 |
65 |
29 |
0.399(0.246-0.648) |
<0.00001 |
| |
HWE(P) |
0.32 |
0.68 |
|
|
0.96 |
0.91 |
|
|
0.56 |
0.68 |
|
|
| rs648893 |
CC |
107 |
116 |
1.00(referent) |
|
55 |
69 |
1.00(referent) |
|
52 |
47 |
1.00(referent) |
|
| |
CT |
113 |
110 |
0.888(0.61-1.292) |
0.54 |
59 |
57 |
0.755(0.453-1.259) |
0.28 |
54 |
53 |
1.102(0.631-1.925) |
0.73 |
| |
TT |
44 |
38 |
0.76(0.455-1.268) |
0.29 |
32 |
28 |
0.671(0.36-1.253) |
0.21 |
12 |
10 |
0.848(0.331-2.171) |
0.73 |
| |
C |
327 |
342 |
1.00(referent) |
|
169 |
195 |
1.00(referent) |
|
158 |
147 |
1.00(referent) |
|
| |
T |
201 |
186 |
0.885(0.689-1.137) |
0.34 |
123 |
113 |
0.796(0.573-1.105) |
|
78 |
73 |
1.006(0.681-1.486) |
0.98 |
| |
HWE(P) |
0.13 |
0.06 |
|
|
0.96 |
0.84 |
|
|
0.38 |
0.21 |
|
|
| rs671531 |
AA |
102 |
109 |
1.00(referent) |
|
56 |
68 |
1.00(referent) |
|
46 |
41 |
1.00(referent) |
|
| |
AG |
116 |
122 |
0.968(0.665-1.408) |
0.87 |
63 |
69 |
0.893(0.544-1.465) |
0.65 |
53 |
53 |
1.091(0.613-1.942) |
0.77 |
| |
GG |
46 |
33 |
0.628(0.37-1.065) |
0.09 |
27 |
17 |
0.482(0.237-0.981) |
0.04 |
19 |
16 |
0.902(0.406-2.004) |
0.8 |
| |
A |
320 |
340 |
1.00(referent) |
|
175 |
205 |
1.00(referent) |
|
145 |
135 |
1.00(referent) |
|
| |
G |
208 |
188 |
0.851(0.663-1.092) |
0.2 |
117 |
103 |
0.752(0.539-1.048) |
0.09 |
91 |
85 |
1.003(0.688-1.463) |
0.99 |
| HWE(P) | 0.2 | 0.08 | 0.95 | 1.00 | 0.67 | 1.00 |
*According to the method of multiplicity correction for SNPs in LD that was introduced by Li & Ji [54], we considered p-values < 0.01 as significant.