Table 3.
Comparison of the genotypic and allelic frequencies of rs1799971 and rs2075572 in different kinds of patients compared with controls by BsmI polymorphisms*
|
SNP |
Gender |
Haplotype |
Controls |
Clinical symptoms |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Delusion of reference | OR(95% CI) | Genuine auditory hallucination | OR(95% CI) | Delusion of persecution | OR(95% CI) | Bizarre behavior) | OR(95% CI) | Apathy | OR(95% CI) | ||||
| rs799971 |
All |
AA |
68 |
53 |
1.00(referent) |
40 |
1.00(referent) |
34 |
1.00(referent) |
51 |
1.00(referent) |
30 |
1.00(referent) |
| |
|
AG |
133 |
92 |
0.888(0.568-1.387) |
78 |
0.997(0.617-1.612) |
69 |
1.038(0.627-1.718) |
101 |
1.013(0.648-1.581) |
57 |
0.971(0.572-1.65) |
| |
|
GG |
63 |
29 |
0.591(0.335-1.042) |
21 |
0.405(0.204-0.803) |
19 |
0.603(0.312,1.164) |
29 |
0.614(0.347-1.086) |
20 |
0.72(0.371-1.394) |
| |
|
A |
269 |
198 |
1.00(referent) |
158 |
1.00(referent) |
137 |
1.00(referent) |
203 |
1.00(referent) |
117 |
1.00(referent) |
| |
|
G |
259 |
150 |
0.787(0.599-1.033) |
120 |
0.789(0.589-1.057) |
107 |
0.811(0.598-1.101) |
159 |
0.813(0.622-1.064) |
97 |
0.861(0.626-1.184) |
| |
Male |
AA |
31 |
26 |
1.00(referent) |
24 |
1.00(referent) |
16 |
1.00(referent) |
21 |
1.00(referent) |
15 |
1.00(referent) |
| |
|
AG |
85 |
45 |
0.631(0.335-1.19) |
48 |
0.729(0.385-1.383) |
32 |
0.729(0.352-1.51) |
44 |
0.764(0.394-1.483) |
46 |
1.118(0.548-2.282) |
| |
|
GG |
30 |
11 |
0.437(0.184-1.039) |
10 |
0.431(0.176-1.051) |
7 |
0.452(0.163-1.254) |
11 |
0.541(0.223-1.312) |
5 |
0.344(0.111-1.066) |
| |
|
A |
147 |
97 |
1.00(referent) |
96 |
1.00(refrent) |
64 |
1.00(referent) |
86 |
1.00(referent) |
76 |
1.00(referent) |
| |
|
G |
145 |
67 |
0.7(0.476-1.031) |
68 |
0.718(0.488-1.057) |
46 |
0.729(0.468-1.135) |
66 |
0.778(0.524-1.154) |
56 |
0.747(0.494-1.131) |
| rs2075572 |
All |
CC |
140 |
91 |
1.00(referent) |
83 |
1.00(referent) |
68 |
1.00(referent) |
90 |
1.00(referent) |
76 |
1.00(referent) |
| |
|
CG |
100 |
69 |
1.062(0.708-1.591) |
49 |
0.827(0.534-1.279) |
43 |
0.885(0.559-1.402) |
78 |
1.213(0.816-1.805) |
29 |
0.534(0.324-0.88) |
| |
|
GG |
24 |
14 |
0.897(0.441-1.825) |
7 |
0.492(0.203-1.192) |
11 |
0.944(0.437-2.038) |
13 |
0.843(0.408-1.74) |
2 |
0.154(0.035-0.667) |
| |
|
C |
380 |
251 |
1.00(referent) |
215 |
1.00(referent) |
179 |
1.00(referent) |
258 |
1.00(referent) |
181 |
1.00(referent) |
| |
|
G |
148 |
97 |
0.992(0.734-1.342) |
63 |
0.752(0.536-1.056) |
65 |
0.932(0.663-1.312) |
104 |
1.035(0.769-1.392) |
33 |
0.468(0.309-0.71) |
| |
Female |
CC |
61 |
35 |
1.00(referent) |
45 |
1.00(referent) |
31 |
1.00(referent) |
25 |
1.00(referent) |
64 |
1.00(referent) |
| |
|
CG |
49 |
20 |
0.711(0.366-1.384) |
27 |
0.747(0.407-1.371) |
24 |
0.854(0.45-1.621) |
27 |
1.344(0.694-2.605) |
19 |
0.37(0.196-0.698) |
| |
|
GG |
8 |
1 |
0.218(0.026-1.815) |
1 |
0.169(0.02-1.404) |
1 |
0.246(0.029-2.056) |
0 |
- |
0 |
- |
| |
|
C |
171 |
90 |
1.00(referent) |
117 |
1.00(referent) |
86 |
1.00(referent) |
77 |
1.00(referent) |
147 |
1.00(referent) |
| G | 65 | 22 | 0.643(0.372-1.111) | 29 | 0.652(0.397-1.072) | 26 | 0.795(0.471-1.342) | 27 | 0.922(0.547-1.557) | 19 | 0.34(0.195-0.593) | ||
*According to the method of multiplicity correction for SNPs in LD that was introduced by Li & Ji [54], we considered p-values < 0.01 as significant.