Table 1.
Type of testicular germ cell tumor in 39 probands# plus degree of relatedness to familial case(s) of TGCT
| |
Degree of relatedness to affected relative |
||||
|---|---|---|---|---|---|
| Type of testicular germ cell tumor in the proband | 1st | 2nd | 3rd | >3rd | Total |
| Seminoma, NOS |
5 |
3 |
4 |
0 |
12 |
| Embryonal carcinoma, NOS |
1 |
3 |
1 |
1 |
6 |
| Teratoma, benign |
0 |
0 |
1 |
0 |
1 |
| Teratocarcinoma |
1 |
0 |
2 |
2 |
5 |
| Choriocarcinoma combined with other germ cell elements |
0 |
0 |
2 |
0 |
2 |
| Yolk sac tumor |
0 |
0 |
1 |
0 |
1 |
| Germ cell tumor, nonseminomatous |
0 |
0 |
1 |
0 |
1 |
| Mixed germ cell tumor (mixed teratoma and seminoma) |
1 |
1 |
0 |
0 |
2 |
| Mixed germ cell tumor (mixed embryonal and seminoma) |
3 |
1 |
2 |
0 |
6 |
| Mixed germ cell tumor (mixed yolk sac and seminoma) |
0 |
0 |
0 |
1 |
1 |
| NSGCT (mixed yolk sac and teratoma, benign) | 0 | 0 | 1 | 0 | 1 |
*First degree- parent, sib, child; second degree - aunt, uncle, grandparent, grandchild; third degree – cousin; more than third – second cousin. If more than one relative affected, only the closest degree of relatedness is included.
NSGCT – Non-seminoma germ cell tumor; NOS – not otherwise specified.
#Family history could not be confirmed for two cases (seminoma and yolk sac tumor) and pathology could not be fully confirmed on a further two cases. These four cases were excluded from the table.