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. Author manuscript; available in PMC: 2013 Oct 1.

Published in final edited form as: Genes Brain Behav. 2012 Sep 7;11(7):806–812. doi: 10.1111/j.1601-183X.2012.00833.x

Table 1.

Acquisition and extinction of conditioned fear in Experiment 1.

	Acquisition^a	Extinction (% Freezing)^b

Genotype	(% Increase in Freezing)	Day 2	Day 3	Day 4	Day 5
apoE2	249.45 ± 28.23	30.09 ± 2.03	29.38 ± 1.84	33.07 ± 2.26	32.47 ± 1.89
apoE3	277.86 ± 49.00	60.00 ± 3.87	50.30 ± 3.44^*	54.59 ± 3.96	46.73 ± 3.30^*
apoE4	395.10 ± 67.14	58.94 ± 3.06	56.32 ± 2.97^†	47.64 ± 2.16^****	46.27 ± 1.86^****
WT	344.08 ± 59.91	44.54 ± 2.6	40.47 ± 2.54	38.77 ± 2.32	37.26 ± 2.19^***

^a

All genotypes exhibited acquisition of fear, as demonstrated by a significant increase in freezing following the first training shock

^b

ApoE3, ApoE4 & WT mice exhibit extinction (significant decrease in freezing relative to day 2).

^*

p < 0.05,

^***

p < 0.005,

^****

p < 0.0001,

^†

p = 0.059. ApoE2 mice do not exhibit extinction.