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. 2013 May 2;8(5):e63163. doi: 10.1371/journal.pone.0063163

Figure 5. WIV-induced maturation of DCs depends on TLR7 activation.

Figure 5

Murine bone marrow-derived wt (black bars) and TLR7−/− (gray bars) DCs were pulsed for 24 hr with WIV, WIV+IRS661, CpG or culture medium. Expression of the following maturation markers was measured by flow cytometry: MHC class I (A), CD86 (B), CD80 (C) and CD40 (D). Gates were set on viable cells based on the forward/sideward scatter profile and exclusion of 7AAD+ cells. Fold changes of mean fluorescence intensity are depicted. Results are representative of 3 independent experiments in each of which 100000 cells were analyzed.