Figure 1. Overview of the distribution of subjects according to the conventional and to the proposed new extended family history definitions.

The graph shows the distribution of participants according to the conventional, guidelines-based definition (cFH) and the proposed new extended Asklepios family history definition (eFH). The new eFH high-risk group is almost identical to the guidelines-defined cFH positives. Seven subjects, categorized as negative in the cFH were categorized as high risk in the eFH (those having at least two second-degree relatives (grandparents) with premature CVD). The new eFH definition mainly differs from the conventional definition (cFH) by sub-stratifying the cFH negative group into two categories in the eFH: a large moderate-risk subgroup and a smaller low-risk subgroup.