Figure 3. Adjusted odds ratios for presence of subclinical atherosclerosis according to the proposed new extended family history definition (eFH) and the conventional definition (cFH).

Odds ratios (95% confidence intervals) for the presence of subclinical atherosclerosis were adjusted for age, sex, total cholesterol, HDL-cholesterol, systolic BP, smoking, DM and BMI. Taking the moderate-risk eFH group as the reference category, odds ratios for prevalent atherosclerosis adjusted for classical risk factors mentioned above are 0.74 (95% CI 0.56–0.98) in the low-risk eFH group versus the moderate-risk eFH group. There was no significant increase in prevalent atherosclerosis when comparing cFH positives versus negatives or eFH high-risk versus moderate-risk categories.