Figure 3. Metabolites and other markers.

Malignant tissue levels of the indicated metabolites were compared for poorer or better prognoses by mitosis, nuclear pleomorphism, and tubule formation indices (panel A) or nodal metastasis (panel B). 13-HODE (panel C) and PGE₂ (panel D) levels were compared by poorer vs. better prognoses for: race, African (closed bars) or Caucasian American (open bars); Her2 score, 2 & 3 (closed bars) or 0 & 1 (open bars); age >50 years (closed bars) or ≤50 years (open bars); body mass index (BMI) >30 (closed bars) or ≤30 (open bars); estrogen receptors (ER) negative (closed bars) or positive (open bars); triple negative (tri (−)) for estrogen, progesterone, & Her2 receptors (closed bars) or not (open bars); tumor size, >2 (closed bars) or ≤ 2 cm (open bars). p Values are from Students t-test corrected for the 3 comparisons in each component of growth (panel A), for the 7 metabolite comparisons (panel B), or for the 7 marker comparisons (panels C and D) by the false discovery rate method. Analysis of these two metabolites for progesterone receptors or for 15-HETE, 12-HETE, 5-HETE, 5-oxo-ETE, and PGD₂ in all 8 marker categories found no significant differences (data not shown).