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The effects of GCDH knockdown and excess lysine on the nuclear morphological changes in rat neurons. Nuclei in uninfected neurons and neurons infected with negative control lentivirus were lightly stained blue. Apoptotic nuclei were deeply stained blue, and appeared dense and fragmented (marked with arrows). Scale bars: 20 µm. The histogram represents the percentage of apoptotic cells. *P<0.05.
