Fig. 2.

Effect of COS on hIAPP amyloid formation. (A) ThT fluorescence intensity of hIAPP (10 μM) at room temperature in the absence and presence of COS at concentrations from 10 to 500 mM. (B) Concentration-dependent inhibition by COS against hIAPP amyloid formation. Data are expressed as a ratio of the ThT fluorescence intensity of hIAPP incubated with COS at each concentration for 24 h to that of the control in the absence of COS. Values are the means ± standard deviations (n = 3). The IC₅₀ values of COS were estimated to be approximately 70 mM.