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(A) Schematic illustration of the variation in copy number of the BRAF gene on digital PCR analysis (CopyCaller). The normal phenotype shows two copies. An increase in the number of copies is associated with overactivation of the Ras/Raf pathway. N = normal pediatric brain tissue. (B) Sequencing of exon 15 in the BRAF gene demonstrating the activating mutation V600E. The black arrow indicates replacement of nucleotide thymine (T) with adenine (A).
