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. 2013 May 2;8(5):e62934. doi: 10.1371/journal.pone.0062934

Figure 1. Effects of nicotinic acid (NA) on mRNA transcription of MCP-1, TNFα, PPARγ, and CD36.

Figure 1

Basal THP-1 macrophages were pre-incubated with LPS prior to administration of NA versus vehicle controls. 1A LPS increased mRNA transcription of MCP-1 and TNFα, while NA treatment attenuated this LPS-induced up-regulation (n = 3 per group). 1B LPS suppressed mRNA transcription of PPARγ and its downstream effector CD36, yet treatment by NA effectively reversed it (n = 3 per group). *P<0.05, **P<0.01, ***P<0.001, ns = non significant.