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. 2013 May 2;8(5):e62934. doi: 10.1371/journal.pone.0062934

Figure 3. Effects of NA and GW1929 on reverse cholesterol transport apparatus: LXRα, ABCA1 and ABCG1.

Figure 3

3A mRNA transcription of all three genes were significantly up-regulated immediately following cholesterol loading but returned to baseline or below-baseline level after resting in standard RPMI media for 24 hours. 3B In basal macrophages, NA significantly up-regulated ABCG1 mRNA transcription (n = 3 per group); this effect was not seen in foam cells. PPARγ activation using GW1929 significantly up-regulated mRNA transcription with both NR1H3 and ABCG1 in both basal macrophages and foam cells. *P<0.05, **P<0.01, ***P<0.001, ns = non significant.