Figure 5. Variation of S-ASM activity in CSF from mouse models and control patients.

A: Comparable activity between human and wildtype (wt/wt) mouse CSF samples, undetectable levels in ASM knock-out mice (ko/ko) and 10-fold higher activity in transgenic mice (wt/tg; number of individuals in brackets). B: Independence of S-ASM activity from the patient’s sex and age. C: No correlation between S-ASM activities in serum and CSF.