Table 4.

Relative Risk Models Predicting Resistance or Susceptibility to World Trade Center-Lung Injury

		Analyte	Cutpoint# ¶	Sample Fraction		Relative Risk(95% CI)
				Cases	Controls	Crude+	Adjusted §
RESISTANT	Single Analyte	MPO	≤105.26	31/68	31/124	2.37(1.26–4.44)	2.92(1.40–6.08)
		sVCAM	≥1568.65	30/68	31/124	2.51(1.34–4.71)	2.26(1.10–4.64)
	Multi-Analyte	MPO	≤105.26	31/68	31/124	2.39(1.26–4.56)	2.89(1.37–6.10)
		sVCAM	≥1568.65	30/68	31/124	2.53(1.34–4.82)	2.24(1.07–4.70)
					AUC	0.647(0.564–0.731)	0.830(0.774–0.887)
SUSCEPTIBLE	Single Analyte	CRP	≥2.45	58/66	85/124	3.33(1.45–7.63)	3.00(1.20–7.47)
		MIP-4	≥194.90	18/66	59/124	0.45(0.24–0.84)	0.37(0.18–0.77)
		Apo AI	≥4220.87	33/66	30/124	3.13(1.66–5.91)	3.61(1.72–7.61)
		Apo AII	≥1772.87	36/66	30/124	3.76(1.99–7.10)	4.04(1.94–8.40)
		Apo CII	≥398.44	29/66	31/124	2.35(1.25–4.43)	2.69(1.29–5.62)
		Apo CIII	≥1058.87	29/66	31/124	2.35(1.25–4.43)	2.71(1.29–5.70)
		Apo E	≥268.71	33/66	31/124	3.00(1.60–5.64)	3.03(1.46–6.30)
	Multi-Analyte	Apo AII	≥1772.87	36/66	30/124	3.51(1.80–6.87)	3.85(1.79–8.26)
		CRP	≥2.45	58/66	85/124	4.01(1.65–9.79)	3.93(1.43–10.79)
		MIP-4	≥194.90	18/66	59/124	0.33(0.16–0.66)	0.26(0.11–0.59)
					AUC	0.767(0.692–0.842)	0.858(0.796–0.919)

^#MIP-4, sVCAM, and MPO in ng/mL, CRP in mg/dL, Apolipoproteins in µg/mL

^¶Cutpoints were based on the 75^th percentile of the Controls for all analytes except MPO (25^th percentile) and CRP ≥2.45

⁺Crude represents the risk without adjusting for any confounders

^§Adjusted: age at 9/11, BMI at SPE, exposure group and pre-9/11 FEV₁% Predicted

Abbreviation Dictionary: Area Under the Curve(AUC)