Table IV.

Risk of death associated with normalized methylation level, n=353, number of deaths=227. HPV status was imputed to be negative for samples from sites other than oropharynx.

	Hazard Ratio	95% CI	P-value
Site: oral cavity
oropharynx	0.723	(0.395, 1.323)	0.292
hypopharynx	0.887	(0.497, 1.584)	0.685
larynx	1.059	(0.699, 1.604)	0.787
other	0.666	(0.337, 1.315)	0.241
multiple	3.847	(1.070, 13.835)	0.039
PNCat: N0 or NX
N1–N3	3.200	(2.246, 4.561)	0.000
Treatment: surgery only
surgery+radiation	0.622	(0.437, 0.886)	0.009
salvage surgery	1.524	(0.969, 2.398)	0.068
unknown	0.677	(0.197, 2.327)	0.535
Gender: female
male	0.990	(0.680, 1.442)	0.958
age	1.023	(1.010, 1.036)	0.000
Smoking: never
pipe or cigar only	0.495	(0.219, 1.122)	0.092
cigarette: <20 pack-yrs	0.796	(0.429, 1.476)	0.469
cigarette: 20–40 pack-yrs	1.036	(0.617, 1.740)	0.894
cigarette: > 40 pack-yrs	1.120	(0.684, 1.836)	0.652
unknown	0.750	(0.218, 2.575)	0.647
Alcohol: < 10 oz/wk
10–32 oz/wk	1.973	(1.326, 2.937)	0.001
>32 oz/wk	1.280	(0.838, 1.955)	0.254
unknown	1.194	(0.634, 2.248)	0.583
P53: wild-type
non-disruptive mutant	1.622	(1.021, 2.578)	0.041
disruptive mutant	1.632	(0.962, 2.770)	0.069
p16	1.008	(1.000, 1.016)	0.045
dcc	1.005	(0.997, 1.013)	0.249
ednrb	1.002	(0.993, 1.011)	0.632
kif	0.997	(0.984, 1.010)	0.642
HPV: no
yes	0.499	(0.212, 1.176)	0.112
unknown	2.312	(0.768, 6.959)	0.136
P53 wild-type
p53 non-disruptive: p16	0.998	(0.986, 1.011)	0.813
p53 disruptive: p16	0.983	(0.968, 0.997)	0.019
p53 non-disruptive: dcc	0.999	(0.986, 1.012)	0.875
p53 disruptive: dcc	1.003	(0.989, 1.018)	0.634
p53n on-disruptive: ednrb	0.987	(0.974, 1.000)	0.053
p53 disruptive: ednrb	0.999	(0.979, 1.019)	0.921
p53 non-disruptive: kif	1.009	(0.991, 1.027)	0.338
p53 disruptive: kif	1.005	(0.984, 1.027)	0.623
p53 non-disruptive: hpv yes	2.300	(0.894, 5.919)	0.084
p53 disruptive: hpv yes	2.196	(0.648, 7.445)	0.207
p53 non-disruptive: hpv unknown	0.738	(0.074, 7.369)	0.796
p53 disruptive: hpv unknown	0.191	(0.021, 1.728)	0.141