Fig. 4.

Immunofluorescence (IF) for HPV16/18 E6 protein in MEC. a, b demonstrate low- and high-power, respectively, of an HPV-positive, cystic, low-grade MEC with proliferation of basaloid type cells. c, e demonstrate hematoxylin and eosin stained areas of a MEC which is HPV positive. d, f represent the corresponding regions demonstrating positive IF staining using an antibody to HPV16/18 E6 protein. Tumor nuclear and cytoplasmic staining is seen (bright green) which correlates with both the glandular and squamoid elements