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. 2013 Mar 15;288(18):12469–12477. doi: 10.1074/jbc.M112.433979

FIGURE 7.

FIGURE 7.

Phosphorylation of Tie2 and Tie2 downstream molecule Erk. A, Ang1 reactivity of Tie2 and Tie2YIA/LAS. After exposure to 200 ng/ml of Ang1, Tie2 and Tie2YIA/LAS phosphorylation was detected in a time-dependent fashion between 0 and 60 min. B, Ang1 reactivity of Tie2 and Tie2YIA/LAS. Ang1-mediated Tie2, Tie2YIA/LAS, and Erk phosphorylation was detected in a dose-dependent fashion between 0 and 500 ng/ml for 10 min. C, Tie2 and Erk phosphorylation on stimulation with 500 ng/ml Ang1 was quantified. The ratio of pTie2/Tie2 or pErk/Erk in cells on stimulation with Ang1 was compared with Ang1-untreated cells. (*, p < 0.05; n = 3).