FIGURE 2.

Analysis of human CCN2 promoter for conserved HREs. A, evolutionarily conserved regions of the CCN2 gene between several vertebrate species, including chimpanzee, bovine, dog, rat, and mouse, are shown using the Evolutionarily Conserved Region (ECR) genome browser. ECR threshold is set at 80%. CCN2 promoter: red, 5′ UTR; yellow, exons; blue, introns; peach, transposons; and simple repeats, green. B, Multiz alignment from UCSC genome database of the three HREs located by the JASPAR database in the human CCN2 promoter (HRE1, HRE2, and HRE3). Non-conserved bases are underlined. *, gaps in alignment; −, no alignment.