Figure 1.
Different criteria for defining universally conserved genes. When 1000 genomes are compared via comparative genomics, the number of orthologous genes falls to 0 (left), but this number can increase to about 500 persistent genes by comparing orthologs that belong to a quorum of a similar or different genomes from evolutionarily distinct bacteria, above a threshold computed using a measure that retains frequent genes that tend to cluster together (right).