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. 2013 May 3;4:244. doi: 10.3389/fpsyg.2013.00244

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Copyright © 2013 Hutchison, Shokri-Kojori, Lu and Rypma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Simulation Results: BOLD as a function of ΔCMRO₂ for different ΔCBF/ΔCMRO₂ coupling ratios within visual cortex. (A) ΔCBF/ΔCMRO₂ coupling ratios derived from fixation for older (red) and younger (blue) participants. (B) ΔCBF/ΔCMRO₂ coupling ratios derived from parafoveal stimulation for older (red) and younger (blue) participants. Variations in BOLD and CMRO₂ were calculated relative to a baseline representing an intermediate activity level for each condition (fixation, parafoveal stimulation).