Table 1. Transgenic mouse lines expressing HCV proteins.

HCV transgene	Genotype	Promoter	Genetic background	Pathology	Cancer frequency	Reference
Polyprotein	1b	Albumin	C57BL/6	Steatosis, HCC	5/37	(Lerat et al 2002)
Core	1a	MUP	C57BL/6 × SJL	none	0*	(Pasquinelli et al 1997)
Core	1b	HBV	C57BL/6	Steatosis, HCC	14-31%	(Moriya et al 1998)
Core	1b	HBV	FVB × C57BL/6	none	0*	(Kamegaya et al 2005)
Core-E1-E2	1b	MHC	C57BL/6		0*	(Honda et al 1999)
Core-E1-E2	1b	Albumin	FVB × C57BL/6	none	0*	(Kamegaya et al 2005)
Core-E1-E2	1a	CMV	B6C3F1	Steatosis, variety of tumors of hepatic and non-hepatic origin	17/185	(Naas et al 2005)
Core-E1-E2	1b	MUP and Albumin	FVB	none	0*	(Kawamura et al 1997)
E1-E2	1b	HBV	CD1	None in liver	0*	(Koike et al 1995)
E2 (a.a. 384-715)	1a	MUP	C57BL/6 × SJL	none	0*	(Pasquinelli et al 1997)
Core-E1-E2-p7	1b	Albumin	C57BL/6	Steatosis, HCC	1/42	(Lerat et al 2002)
NS5A	1a	apoE	FVB	none	0/72	(Majumder et al 2003)
NS5A	1a	MUP	FVB	none	0/40	(Majumder et al 2003)
NS5A	1b	HBV	C57BL/6J × CBA/J	Steatosis, tumors	10/163	(Wang et al 2009a)

^*total number of mice in study was not stated.