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Activities of C6orf130 on poly(ADP-ribosyl)ated PARP1 substrates. (A) Hydrolysis of PAR by C6orf130 and PARG analysed by SDS–PAGE and (B) by thin-layer chromatography-based assays. (C) C6orf130 inhibits automodification activity of PARP1 in vitro.
